Table 1.

A brief timeline of the relationship between blood vessels and cancer.

1787	Hunter firstly used the term “angiogenesis”.
1907	Goldmann visualized angiogenesis.
1934	Detailed description of intra-alveolar growth of lung metastatic tumors spreading from one alveolus to another through the alveolar pores.
1939	Vascularization of the Brown Pearce rabbit epithelioma transplant in the transparent ear chamber in rabbits.
1956	Proliferation of cancer cells alongside hepatocellular trabeculae with a replacement pattern.
1962	Florey’s General Pathology textbook states that sometime a tumor supplement or replace the stroma using of pre-existing structures like the alveolar walls.
1971	Folkman introduces the hypothesis that tumor growth is dependent on angiogenesis.
1974	Robbins’ textbook describes that sometime metastatic cancer cells will grow in the lung without destruction of the lung parenchyma in a fashion resembling bacterial pneumonia.
1980	Demonstration that inhibition of angiogenesis suppresses tumor growth in animal models.
1988	Trabecular growth of hepatocellular carcinoma and intra-alveolar growth of primary lung carcinomas.
1996	First description of non-angiogenic tumors.
1999	First description of vascular co-option in a mouse model.
1999	First description of vasculogenic mimicry.