Figure 4.

Taking advantage of the detailed analyses performed on the local translatome in astroglial peripheral processes [111,130] and on the axonal transcriptome of Aβ-treated axons [14], a GO term analysis of common localized transcripts found in astrocytes and neurons is shown (FDR < 0.05) (A). Focusing on significantly changed transcripts in Aβ-treated axons compared to controls (¹), 21 one of them are also found in perisynaptic astrocytic process (PAP) translatome datasets (²) (B). Local translation occurs both in PAPs (upper table) and in perivascular astrocytic processes (PvAPs) (lower table). Arrows indicate altered levels (red, increase; green, decrease) of mRNAs and/or proteins in diseases (C). n.d, not described.