Figure 2.

Human telomerase reverse transcriptase (TERT) promoter region and binding sites for various transcription factors, repressors, and repressive chromatin markers. The specific mutations relative to ATG and hypermethylated regions relative to upstream of the transcription start site (UTSS) (TERT hypermethylated oncological region—THOR) are represented. Cancer-specific mutations control the recruitment of GABP transcription factor to the promoter and increase gene expression. Methylation of promoter potentially controls transcriptional activator (MYC) and repressor (WT1 and CTCF) recruitment to target sites, leading to high expression. Green box active histone marks, red box repressive marks. Black dots show methylated cytosines followed by guanine residue (CpG) sites. ETS: E-twenty-six; TSS: transcription start site.