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. 2021 Mar 3;10(3):532. doi: 10.3390/cells10030532

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of ATM reduction on the progression of cystic kidney disease in Pkd1^RC/RC mice at 3 months of age. (A) Representative macroscopic appearance of male Pkd1^RC/RC mice either with Atm^+/+ (wild-type), Atm^+/− (heterozygous), or Atm^−/− (homozygous) genotype, and this was similar in all experimental groups. (B) and (C) Representative images of Pkd1^RC/RC mouse kidneys with either Atm^+/+ or Atm^−/− genotype. (D) Mean body weight of the experimental groups. (E) Mean two kidney weight to body weight ratio (KW: BW) in the experimental groups. * p < 0.05 compared to wild-type mice (Pkd1^+/+/Atm^+/+) and # p < 0.05 compared to Atm genotype matched Pkd1^+/+. Data presented as means ± SD (n = 8 per wild-type group; n = 4 males and n = 4 females; n = 20 per Pkd1^RC/RC mouse group; n = 10 males and n = 10 females).