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. 2021 Mar 3;10(3):532. doi: 10.3390/cells10030532

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of loss of ATM on renal histology in Pkd1^RC/RC mice at 3 months of age. (A,B) Representative whole-slide digital images of Periodic Acid Schiff (PAS)-stained kidney sections from male wild-type (A) Pkd1^RC/RC (B) mice. Scale bars in top panel indicates 2.5 mm and bottom panel 0.25 mm. (C) Mean percentage cyst area in the experimental groups calculated as the percentage of white area (no stain) in the total cortical area. * p < 0.05 compared to wild-type mice (Pkd1^+/+/Atm^+/+) and # p < 0.05 compared to Atm genotype matched Pkd1^+/+. Data presented as means ± SD (n = 8 per wild-type group; n = 4 males and n = 4 females; n = 20 per Pkd1^RC/RC mouse group; n = 10 males and n = 10 females).