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. 2021 Mar 13;11(3):201. doi: 10.3390/jpm11030201

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Approach for generating a precision endoxifen prediction algorithm to enable personalized tamoxifen dosing. A precision endoxifen prediction algorithm that integrates clinical and genetic variables could be generated from existing datasets. The algorithm would then be used to validate the association of endoxifen concentration with tamoxifen efficacy and identify the target endoxifen concentration. This information could then be used to inform personalized dosing that maximizes tamoxifen treatment efficacy.