Table 4.

Non-CYP2D6 Enzymes associated with tamoxifen, endoxifen, or other metabolites.

Gene	Variants	Metabolites Measured	Reported Association	Ref.
CYP2C9	*2 and *3	Tam, 4OHtam, endoxifen, glucuronides, E and Z	Lower 4OHtam and endoxifen	[28]
	*2 and *3	Tam, NDtam, 4OHtam, endoxifen, N,N-DDtam, norendoxifen	Lower 4OHtam/tam ratio	[5]
	*1–*11	Endoxifen	Lower endoxifen and end/4OHtam ratio	[73]
	*2 and *3	Endoxifen	Lower endoxifen	[72]
CYP2C19	*2	Tamoxifen, NDtam, tamNoX, Z-4′-OH-Tam, Z-4OH-tam, Z-endoxifen, Z-4′-endoxifen	Higher Tam/4OHtam ratio	[70]
	*2, *3, *17	Endoxifen	Higher 4OHtam	[73]
	*2, *3, *17	Tam, NDtam, 4OHtam, endoxifen, N,N-DDtam, norendoxifen	Lower norendoxifen/N,N-DD-tam ratio	[5]
	*2, *3, *17	Tam, 4OHtam, NDtam	Higher 4OHtam/tam ratio	[99]
CYP3A4	*22	Endoxifen	Higher endoxifen	[67]
	*22	Tamoxifen, NDtam, tamNoX, Z-4′-OHtam, Z-4-OH-tam, Z-endoxifen, Z-4′-endoxifen	Higher endoxifen	[70]
SULT1A1	rs6839, rs1042157	Tamoxifen, endoxifen, 4OHtam and NDtam	Higher endoxifen and 4OHtam	[119]
SULT1A2	*2 and *3	Tam, 4OHtam, NDtam, endoxifen, TamNoX	Higher endoxifen and 4OH-tam	[82]
UGT1A4	Leu48Val	Tam, 4OHtam, endoxifen, glucuronides, E and Z	Lower tam/Tam-N-glucoronide ratio	[28]
	Leu48Val	Glucuronidated metabolites of endoxifen and 4OHtam	Lower 4OHtam-N-Gluc and endoxifen-gluc	[125]
	Leu48Val	Tamoxifen, E and Z-endoxifen, E- and Z-4-OHtam and the corresponding glucuronides	Higher Tam-N-gluc	[123]
UGT2B7	*2 (His268Tyr)	Tam and endoxifen	Higher endoxifen	[81]
	*2 (His268Tyr)	Glucuronidated metabolites of endoxifen and 4OHtam	Higher Tam, 4OHtam, NDtam. Lower 4OHtam-O-gluc and 4-OH-Tam-N-gluc	[125]
UGT2B15	Lys523Thr	Glucuronidated metabolites of endoxifen and 4OHtam	Higher 4-OH-Tam-O-gluc and endoxifen-gluc	[125]
UGT2B17	Deletion	Glucuronidated metabolites of endoxifen and 4OHtam	Higher 4OHtam-N-gluc	[125]