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A schematic representation of the polypeptide chain of human super-family 2 DNA helicases containing an Fe–S cluster is reported. Color code is as follows: blue, conserved helicase motifs (Q motif, Q, and helicase boxes from I to VI); grey, Timeless-binding motif (T) [12]; orange, Fe–S cluster (Fe–S) and pale blue, Arch domain (Arch) domain.
