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. 2021 Mar 10;13(3):365. doi: 10.3390/pharmaceutics13030365

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ACPPs are cleaved in situ within murine tumors. (A) Structural representation of ratiometric activatable cell penetrating peptide probe with intervening MMP-2/9 protease sensitive amino acid sequence. (B) Mice with subcutaneous syngeneic LL2 tumors tail vein injected with 10 nanomoles ratiometric ACPP. In situ mouse imaging for Cy5:Cy7 emission ratio shown. Cy5:Cy7 emission ratio pseudocolor scale bar shown on far right. (C) Confocal imaging of tissue from LL2 tumor bearing mice injected with ratiometric ACPP. Tissue section containing tumor and adjacent muscle imaged for Cy5 (Red). Nuclei DAPI stained (Blue).