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. 2021 Mar 6;13(3):344. doi: 10.3390/pharmaceutics13030344

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Contour and 3D response surface plot of dependent variables against independent variables: X1, PVP VA64 ratio; X2, barrel temperature (°C); Y1, content (%); Y2, dissolution rate (%) in SGF (2 h); Y3, dissolution rate (%) in SGF (6 h); Y4, dissolution rate (%) in SIF (2 h); Y5, dissolution rate (%) in SIF (6 h).

Contour and 3D response surface plot of dependent variables against independent variables: X1, PVP VA64 ratio; X2, barrel temperature (°C); Y1, content (%); Y2, dissolution rate (%) in SGF (2 h); Y3, dissolution rate (%) in SGF (6 h); Y4, dissolution rate (%) in SIF (2 h); Y5, dissolution rate (%) in SIF (6 h).