Table 1.
Formulation of hot-melt extruded RXB-ASDs using various polymer mixtures.
| Formulation | w/w Ratio | Content (%) | Dissolution Rate (%) | |||||
|---|---|---|---|---|---|---|---|---|
| RXB | Soluplus® | PVP VA 64 | PVA | Cremophor® RH 40 | Gelucire® 50/13 | |||
| F1 | 1 | 2 | - | - | - | - | 89.63 ± 3.31 | 24.52 ± 4.13 |
| F2 | 1 | 4 | - | - | - | - | 90.56 ± 4.36 | 24.66 ±12.94 |
| F3 | 1 | - | 2 | - | - | - | 94.05 ± 3.33 | 46.57 ± 0.57 |
| F4 | 1 | - | 4 | - | - | - | 97.01 ± 1.24 | 51.89 ± 0.46 |
| F5 | 1 | 2 | 2 | - | - | - | 91.26 ± 6.77 | 18.83 ± 4.32 |
| F6 | 1 | 4 | - | 1 | - | - | 76.05 ± 2.23 | 52.72 ± 2.19 |
| F7 | 1 | 4 | - | - | 1 | - | 92.48 ± 1.33 | 35.82 ± 6.61 |
| F8 | 1 | 4 | - | - | - | 1 | 93.70 ± 1.48 | 33.44 ± 0.48 |
| F9 | 1 | - | 4 | 1 | - | - | 73.78 ± 1.77 | 80.80 ± 1.16 |
| F10 | 1 | - | 4 | - | 1 | - | 93.58 ± 1.26 | 83.29 ± 0.33 |
| F11 | 1 | - | 4 | - | - | 1 | 95.38 ± 1.26 | 73.80 ± 3.76 |