Table 1.

In vitro Cyclooxygenase-1/2 and 5-LOX Inhibitions of the Michael Products

Compound No.	IC50 (μM)a ±SEM		Selectivity Index (SI) (IC50 COX-1/IC50 COX-2)	IC50 (μM) ±SEM
	COX-1	COX-2		5-LOX
4	128.1±1.21	65.91±1.06	1.94	19.22±0.20
9	67.59±1.02	73.53±1.38	0.91	23.01±1.03
10	57.40±2.02	49.68±0.18	1.15	11.43±0.63
11	46.09±2.20	5.79±0.23	7.96	1.06±0.02
Indomethacin	0.53±0.03	4.68±1.08	0.11
Zileuton				0.69±0.01

Note: ^aAll the experiments are performed in triplicate.