Table 3.
Tail Flick Method Results of the Michael Products 4 and 11
| Treatment/Dose | Time in Seconds (Tail Flick)/Response (%) | |||||
|---|---|---|---|---|---|---|
| 15 Minutes | 30 Minutes | 45 Minutes | 60 Minutes | 75 Minutes | 90 Minutes | |
| Control (2% Tween 80) | 0.81±0.015 | 0.88±0.035 | 0.98±0.026 | 0.95±0.034 | 0.88±0.025 | 0.91±0.043 |
| Comp 4 (25 mg) | 11.1% | 14.8% | 16.3% | 18.9% | 29.5% | 19. 8% |
| Comp 4 (50 mg) | 14.8% | 22.7% | 33.7% | 42.1% | 53.4% | 46.2% |
| Comp 11 (25 mg) | 15.2% | 19.3% | 26.4% | 35.1% | 42.2% | 34.1% |
| Comp 11 (50 mg) | 21.6% | 28.3% | 46.8% | 54.1% | 63.5% | 58.7% |
| Morphine (5 mg) | 48.1% | 56.1% | 75% | 85% | 80.2% | 78.4% |