Table 4.
Formalin-Induced Paw-Licking Response for Elucidation of Central Analgesic Pathway of Compounds 4 and 11
| Treatment/Dose | Licking Time (Seconds) | Inhibition (%) | ||
|---|---|---|---|---|
| 1st Phase | 2nd Phase | 1st Phase | 2nd Phase | |
| Control (2% Tween 80) | 50.65±1.25 | 73.90±1.45 | —– | —– |
| Compound 4 (25 mg) | 39.35±1.231*** | 45.12±1.145*** | 22.30±0.85 | 38.94±2.88 |
| Compound 4 (50 mg) | 32.33±1.356** | 36.45±1.232*** | 36.16±4.47 | 50.66±3.84 |
| Compound 11 (25 mg) | 39.85±1.278*** | 52.53±1.251*** | 21.32 | 28.91 |
| Compound 11 (50 mg) | 33.60±1.457** | 38.59±1.336*** | 33.66 | 47.78 |
| Indomethacin (10 mg) | 38.65±1.37** | 18.96±1.342*** | 23.69±3.24 | 74.34±2.86 |
| Morphine (5 mg) | 6.50±1.153*** | 2.70±1.340*** | 87.16±3.32 | 96.34±0.66 |
| N+4 (25 mg) | 41.80±1.33 | 48.95±1.40 | 17.47±1.89 | 33.76±2.53 |
| N+4 (50 mg) | 38.65±1.25 | 42.75±1.65 | 23.69±1.44 | 42.15±1.43 |
| N+11 (25 mg) | 42.75±1.25 | 59.80±1.70 | 15.59 | 19.07 |
| N+11 (50 mg) | 41.45±1.30 | 44.60±1.236 | 18.16 | 39.64 |
| N+Indomethacin (10 mg) | 44.75±1.76** | 25.00±1.249*** | 11.64±1.20 | 65.17±2,74 |
| N+Morphine (5 mg) | 49.29±1.52 | 72.83±1.152 | 2.68±1.20 | 1.44±0.28 |
Note: The observed values are represented as ±SEM (**P<0.01 and ***P<0.001 in comparison to the control).