Table 7.

Interaction with the Amino Acid Residues and Binding Energy Value of the Compounds

Compound No.	COX-1		COX-2
	Key Amino Acids	Binding Energy (kcal/mo1)	Key Amino Acids	Binding Energy (kcal/mo1)
4	Arg120, Tyr355	−6.4259	Arg120, Tyr355	−6.8730
4-COOH	Tyr355, Ser530	−8.3497	Arg120, Tyr355	−7.7722
9	Val349, Ala527, Ser530	–6.7320	Arg120, Tyr355	−6.7810
10	Tyr385, Mt522, Ser530	−6.7974	Tyr385, Mt522	−7.1772
11	Val116, Tyr355, Trp387	−7.0115	Arg120, Ser353, Tyr355, Arg513	−8.5834