Table 2.
Tissue and organ Cr levels in control and doxepin-treated obese mice over 56 treatment days.
| Variable | Control | Doxepin |
|---|---|---|
| Chromium intake/mouse/week (μg) | 19.37 ± 0.51 | 27.28 ± 0.82 ** |
| Blood (ng/mL) | 162.16 ± 7.67 | 90.43 ± 6.74 *** |
| Bone (ng/g) | 367.19 ± 10.42 | 172.13 ± 8.41 *** |
| Liver (ng/g) | 70.24 ± 6.85 | 51.39 ± 3.82 ** |
| Muscle (ng/g) | 50.69 ± 4.72 | 38.54 ± 3.25 ** |
| Epididymal fat pads (ng/g) | 45.31 ± 2.08 | 34.65 ± 1.94 ** |
| Kidney (ng/g) | 99.78 ± 2.81 | 181.63 ± 3.34 *** |
| Urine (ng/mL) | 56.73± 2.03 | 105.52 ± 2.55 *** |
All values represent the mean ± standard deviation (n = 10 for all groups). ** p < 0.01 and *** p < 0.001 indicate high and very high statistical significance, respectively.