Table 1.
Characteristics of Clinical Studies Using Dinitrochlorobenzene for the Treatment of Alopecia Areata
| Author(s), Year | Study Design | Number of Patients | Age, Years, Range | Type of AA, n | Duration of Therapy, Months | Complete Response, n (%) | Partial Response, n (%) | Relapse Rate, n (%) |
|---|---|---|---|---|---|---|---|---|
| Breuillard and Szapiro, 197861 | Prospective study | 30 | 6–59 | AT=27, other=3 | NS | 11 (36.6) | 10 (33.3) | NS |
| Friedman, 198162 | Prospective study | 51 | 12–72 | AT=38 | 5–6.6 | 3 (5.8) | 27 (52.9) | NS |
| Swanson et al, 198163 | RCT | 22 (DNCB=12) | 16–68 | AT/AU=13, other=9 | 6 | 0 | 7 (63.3) (spontaneous hair regrowth=1) | 0 |
| Singla et al, 199164 | Prospective study | 50 (DNCB=25) | NS | NS | 4 | 4 (16) | 12 (48) | NS |
| Yoshizawa et al, 200265 | Prospective study | 20 | 12–64 (mean=31.9) | AT=2, <50%, AA=18 | 5 | 5 (25) | 10 (50) | NS |
Abbreviations: AA, alopecia areata; AT, alopecia totalis; AU, alopecia universalis; DNCB, dinitrochlorobenzene; NS, not stated; RCT, randomized controlled trial.