Table 2.
Results of emulation of clinical trials on head-to-head comparison of antipsychotics for the outcomes of SREs with truncating weights.
| Drug Pair | Hazard Ratio * 95% Confidence Interval (Adjusting Comorbidities) | p Value | Q Value ** | Hazard Ratio 95% Confidence Interval (Adjusting Comorbidities + Concomitant Drugs) | p Value | Q Value ** |
|---|---|---|---|---|---|---|
| Aripiprazole vs. Haloperidol | 0.73 [0.437, 1.22] | 0.233 | 0.2610 | 0.44 [0.25, 0.79] | 0.0062 | 0.0154 |
| Aripiprazole vs. Lurasidone | 15.4 [8.65, 27.5] | <0.0001 | <0.0004 | 43.25 [10.65, 175.56] | <0.0001 | <0.0004 |
| Aripiprazole vs. Olanzapine | 0.70 [0.421, 1.15] | 0.1599 | 0.2356 | 0.75 [0.41, 1.39] | 0.3594 | 0.4193 |
| Aripiprazole vs. Perphenazine | 2.27 [0.847, 6.06] | 0.1034 | 0.1756 | 1.09 [0.49, 2.44] | 0.8319 | 0.8627 |
| Aripiprazole vs. Quetiapine | 1.41 [0.919, 2.17] | 0.1159 | 0.1803 | 2.05 [1.28, 3.28] | 0.0028 | 0.0087 |
| Aripiprazole vs. Risperidone | 1.37 [0.846, 2.22] | 0.2002 | 0.2372 | 2.20 [1.21, 4.01] | 0.0101 | 0.0202 |
| Aripiprazole vs. Ziprasidone | 0.68 [0.373, 1.23] | 0.2033 | 0.2372 | 0.98 [0.52, 1.85] | 0.9542 | 0.9542 |
| Haloperidol vs. Lurasidone | 23.2 [7.68, 70.2] | <0.0001 | <0.0004 | 52.20 [14.97, 182.18] | <0.0001 | <0.0004 |
| Haloperidol vs. Olanzapine | 1.05 [0.547, 2.00] | 0.8938 | 0.9269 | 1.86 [1.02, 3.42] | 0.0447 | 0.0834 |
| Haloperidol vs. Perphenazine | 4.25 [1.23, 14.7] | 0.0219 | 0.0472 | 1.97 [0.80, 4.84] | 0.1399 | 0.1996 |
| Haloperidol vs. Quetiapine | 1.73 [1.038, 2.87] | 0.0354 | 0.0661 | 1.62 [0.86, 3.05] | 0.1321 | 0.1996 |
| Haloperidol vs. Risperidone | 1.72 [0.89, 3.31] | 0.1066 | 0.1756 | 3.20 [1.47, 6.97] | 0.0033 | 0.0092 |
| Haloperidol vs. Ziprasidone | 0.590 [0.27, 1.30] | 0.1897 | 0.2372 | 1.81 [0.82, 3.98] | 0.1426 | 0.1996 |
| Lurasidone vs. Olanzapine | 0.057 [0.031, 0.10] | <0.0001 | <0.0004 | 0.01 [0.002, 0.04] | <0.0001 | <0.0004 |
| Lurasidone vs. Perphenazine | 0.13 [0.064, 0.28] | <0.0001 | <0.0004 | 0.17 [0.01, 2.41] | 0.1904 | 0.2423 |
| Lurasidone vs. Quetiapine | 0.12 [0.077, 0.18] | <0.0001 | <0.0004 | 0.05 [0.02, 0.16] | <0.0001 | <0.0004 |
| Lurasidone vs. Risperidone | 0.13 [0.073, 0.25] | <0.0001 | <0.0004 | 0.24 [0.14, 0.40] | <0.0001 | <0.0004 |
| Lurasidone vs. Ziprasidone | 0.065 [0.033, 0.13] | <0.0001 | <0.0004 | 0.05 [0.02, 0.11] | <0.0001 | <0.0004 |
| Olanzapine vs. Perphenazine | 2.945 [1.15, 7.58] | 0.025 | 0.0500 | 0.66 [0.30, 1.43] | 0.2901 | 0.3532 |
| Olanzapine vs. Quetiapine | 1.813 [1.104, 2.98] | 0.0188 | 0.0439 | 1.95 [1.20, 3.15] | 0.0066 | 0.0154 |
| Olanzapine vs. Risperidone | 2.153 [1.15, 4.02] | 0.0161 | 0.0439 | 2.35 [1.41, 3.94] | 0.0011 | 0.0039 |
| Olanzapine vs. Ziprasidone | 0.882 [0.43, 1.80] | 0.7296 | 0.7857 | 1.61 [0.83, 3.11] | 0.1572 | 0.2096 |
| Perphenazine vs. Quetiapine | 0.541 [0.22, 1.33] | 0.1801 | 0.2372 | 1.22 [0.48, 3.11] | 0.677 | 0.7582 |
| Perphenazine vs. Risperidone | 0.506 [0.18, 1.40] | 0.188 | 0.2372 | 2.55 [1.27, 5.14] | 0.0087 | 0.0187 |
| Perphenazine vs. Ziprasidone | 0.315 [0.12, 0.82] | 0.0176 | 0.0439 | 1.93 [0.81, 4.59] | 0.1358 | 0.1996 |
| Quetiapine vs. Risperidone | 1.024 [0.60, 1.75] | 0.9286 | 0.9286 | 1.08 [0.64, 1.80] | 0.7762 | 0.8359 |
| Quetiapine vs. Ziprasidone | 0.451 [0.24, 0.84] | 0.0118 | 0.0367 | 0.59 [0.32, 1.08] | 0.0866 | 0.1516 |
| Risperidone vs. Ziprasidone | 0.432 [0.23, 0.83] | 0.0118 | 0.0367 | 0.30 [0.17, 0.52] | <0.0001 | <0.0004 |
* Hazard ratio: the first drug vs. the second drug. Numbers represented in brackets indicate the 95% confidence intervals. ** Q values were generated by adjusting false discovery rate from p values.