Use of nanoparticles and high-affinity ligands to target cancer and increase the spatial resolution of photothermal therapy (PTT): (a) nanoparticle accumulation in cancer cells through cancer-target ligands, where either the nanoparticles or the ligands can come from a wide range of materials; (b) scheme of drug accumulation in the cancer site—step 1 shows the nanoparticle injection, step 2 evidences the nanoparticle distribution in the human body, step 3 shows the nanoparticle accumulation in the tumor, step 4 highlights the photonic nanomedicine being used, and step 5 shows the complete tumor regression after the therapy. Copyright (2020) Springer Nature Limited. Source [30].