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. 2021 Mar 5;9(3):222. doi: 10.3390/vaccines9030222

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Semi-synthetic MS derivative VSA-2. Mice were immunized by the s.c. route with rHagB alone or with GPI-0100 or a saponin adjuvant on days 0, 14, and 28. Serum samples were collected prior to each immunization and at 6 weeks after the initial immunization. IgG2a/IgG1. Values are expressed as mean ± SD. Statistical significance compared with rHagB + VSA-2 (21). Statistical significance was evaluated by t tests (with unpaired, nonparametric, and Mann−Whitney test). * p < 0.05; ** p < 0.01.

Semi-synthetic MS derivative VSA-2. Mice were immunized by the s.c. route with rHagB alone or with GPI-0100 or a saponin adjuvant on days 0, 14, and 28. Serum samples were collected prior to each immunization and at 6 weeks after the initial immunization. IgG2a/IgG1. Values are expressed as mean ± SD. Statistical significance compared with rHagB + VSA-2 (21). Statistical significance was evaluated by t tests (with unpaired, nonparametric, and Mann−Whitney test). * p < 0.05; ** p < 0.01.