Skip to main content
. 2021 Mar 15;22(6):2974. doi: 10.3390/ijms22062974

Figure 4.

Figure 4

Resistance to treatment in PER1-overexpressing tumors. (A) Tumor volume over time of A549-GFP and A549-PER1 subcutaneous tumor xenografts in NSG mice treated with cisplatin. Black arrow: first day of treatment with cisplatin at the concentration of 5 mg/kg, repeated every 3 days for two weeks. Bars represent average ± SEM (n=4 mice). (**) p < 0.01. (B) Tumor volume and tumor weight after 15 days of treatment as in (A). Bars represent average ± SEM (n = 4 mice). (*) p < 0.05. (C) Control of Per1 level of expression in A549-GFP (CTRL) and A549-PER1 (PER1) subcutaneous tumors, evaluated by qPCR. Bars represent average ± SD (n = 4 mice). (D) Representative images of gross histology, histology (H&E staining) and tumor cell death (TUNEL). 40× magnification (scale bars, 100 μm).