Table 3.

Association of BMI with methylation of clock genes.

Log (Clock Genes)	β 1	Lower CI	Upper CI	p-Value	q-FDR
BMAL1	−0.002	−0.012	0.008	0.698	0.698
CLOCK	−0.005	−0.024	0.015	0.642	0.351
CRY1	0.01	−0.007	0.026	0.251	0.191
CRY2	0.012	−0.001	0.025	0.065	0.191
PER1	0.012	0	0.024	0.058	0.282
PER2	0.001	0	0.003	0.161	0.191
PER3	0.001	0	0.003	0.082	0.698

¹ Multivariable regression models applied to logarithmic transformation of rate of methylation of clock genes, adjusted for HOMA-IR index, percentage of neutrophils, homocysteine plasma level, CpG dinucleotide position. BMAL1: Brain and Muscle Aryl Hydrocarbon Receptor Nuclear Translocator-like Protein-1; CI: Confidence Interval; CLOCK: Circadian Locomotor Output Cycles Kaput; CRY: Cryptochrome Circadian Regulator; PER: Period Circadian Regulator; q-FDR: False Discovery Rate.