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A hypothetical module of KEAP1–ABI5 in plants. Under physiological conditions, ABI5 is degraded and unable to activate its target genes (including itself) (A). When there is a high level of ABA (B) or under stress (C), the configuration of KEAP1 is changed due to reactions with electrophiles, and ABI5 is released from the complex. ABI5 is then phosphorylated and translocated to the nucleus and activates the transcription of target genes.
