Table 1.

Screening of (R) and (S)-tryptophanol-derived oxazolopyrrolidone lactams 7a–g and 8a–g in AGS cell line.

Compound	R1	R2	% CV at 100 µM 1
7a	H	H	50 ± 5
7b	F	H	50 ± 8
7c	Cl	H	6 ± 1
7d	Br	H	14 ± 3
7e	CH3	H	14 ± 2
7f	OCH3	H	18 ± 2
7g	SO2CH3	H	94 ± 12
8a	H	H	58 ± 4
8b	F	H	22 ± 4
8c	Cl	H	11 ± 1
8d	Br	H	25 ± 4
8e	CH3	H	60 ± 3
8f	OCH3	H	30 ± 4
8g	SO2CH3	H	91 ± 11

¹ Each % of CV (cell viability) value is the mean ± SD of triplicate of at least two different experiments. % CV determined by the MTT method after 48 h of compounds’ incubation.