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. 2021 Mar 15;19(3):152. doi: 10.3390/md19030152

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of phlorotannins on levels of ADAM10, BACE1, and PS1 in SweAPP N2a cells. Western blotting was carried out to detect the expression of APP proteolytic enzymes. (a) Immunoblot bands and the quantifications of (b) ADAM10, (c) BACE1, and (d) PS1. The SweAPP N2a cells were incubated with phlorotannins (1, 10, and 50 μM) for 24 h. β-Actin was used as a normalizing control in the western blot assay. The values are shown as the means ± SD from 3 independent experiments with 3 replications in each experiment. Black dots represent individual data point. *** p < 0.001, ** p < 0.01 and * p < 0.05 compared with control group.

Effects of phlorotannins on levels of ADAM10, BACE1, and PS1 in SweAPP N2a cells. Western blotting was carried out to detect the expression of APP proteolytic enzymes. (a) Immunoblot bands and the quantifications of (b) ADAM10, (c) BACE1, and (d) PS1. The SweAPP N2a cells were incubated with phlorotannins (1, 10, and 50 μM) for 24 h. β-Actin was used as a normalizing control in the western blot assay. The values are shown as the means ± SD from 3 independent experiments with 3 replications in each experiment. Black dots represent individual data point. *** p < 0.001, ** p < 0.01 and * p < 0.05 compared with control group.