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. 2021 Mar 14;13(6):1292. doi: 10.3390/cancers13061292

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Specificity of various types of BCl-2 inhibitors and induction of apoptosis. Targeting the Bcl-2 pro-survival proteins by various inhibitors with different specificity (ABT-737/ABT-263, obatoclax, or venetoclax) leads to BAX/BAK activation and pores formation through which cytochrome c is released into the cytosol culminating in apoptosis induction.