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. 2021 Mar 8;11(3):399. doi: 10.3390/biom11030399

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) The scheme of DNA biosensor for detecting metal ion including Hg²⁺ based on the Cu²⁺-specific DNAzyme and G-quadruplex DNAzymes. (b) The Cu²⁺-specific DNAzyme, (c) Pb²⁺-specific DNAzyme, and (d) the modified Cu²⁺-specific DNAzyme for Hg²⁺ biosensor. Reprinted with permission from [85]. Copyright 2012 Elsevier.