Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The AAPs-induced metabolic syndrome (MetS) is the consequence of a broad activity of these drugs on the central nervous system (CNS) and peripheral organs. In the CNS, the most important target is the hypothalamus, while in the periphery, the liver, pancreatic β-cells, adipose tissue and skeletal muscle are implicated in AAPs-induced MetS. By interfering with the activity of different GPCRs expressed in these regions, AAPs significantly alter glucose and lipid homeostasis.
