Figure 1.

Ventricular action potential and underlying ionic currents (adapted from [32,61,63]). Schematic representation of human ventricular and human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) action potential waveforms (a) with indicated in grey: action potential (AP) phases (on ventricular AP waveform) as well as action potential amplitude (APA), action potential duration (APD) and resting membrane potential (RMP) (on iPSC-CM AP waveform). Bottom panel represents the relative magnitude of the underlying ionic currents (b) together with the list of genes (in black) encoding alpha and auxiliary (beta) ion channel protein subunits (in red) which cooperate in generation of the represented ion currents (created with biorender.com December 2020).