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. 2021 Mar 10;11(3):491. doi: 10.3390/diagnostics11030491

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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As the Kaplan-Meier curve illustrates, an IRS value ≥2 of the nuclear PPARγ expression is related to a longer overall survival than in patients with lower values ((A), * p = 0.019). Here, a prognostic survival advantage is shown in contrast to the contrary trend in the Kaplan-Meier curve in Figure 4B. The blue line in Figure 4A shows the survival curve of patients with nuclear PPARγ expression of IRS level under 2, the red line shows the survival curve of patients with nuclear PPARγ expression IRS level ≥2. (B) reveals an opposite trend in the overall survival curve as soon as PPARγ expression is detected in the cytoplasm rather than in the nucleus (B), p = 0.053). The blue line in (B) shows the survival curve of patients with PPARγ expression in cytoplasm of IRS level under 2, the red line shows the survival curve of patients with PPARγ expression in cytoplasm of IRS level ≥ 2.

As the Kaplan-Meier curve illustrates, an IRS value ≥2 of the nuclear PPARγ expression is related to a longer overall survival than in patients with lower values ((A), * p = 0.019). Here, a prognostic survival advantage is shown in contrast to the contrary trend in the Kaplan-Meier curve in Figure 4B. The blue line in Figure 4A shows the survival curve of patients with nuclear PPARγ expression of IRS level under 2, the red line shows the survival curve of patients with nuclear PPARγ expression IRS level ≥2. (B) reveals an opposite trend in the overall survival curve as soon as PPARγ expression is detected in the cytoplasm rather than in the nucleus (B), p = 0.053). The blue line in (B) shows the survival curve of patients with PPARγ expression in cytoplasm of IRS level under 2, the red line shows the survival curve of patients with PPARγ expression in cytoplasm of IRS level ≥ 2.