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. 2021 Mar 12;19(3):148. doi: 10.3390/md19030148

Figure 6.

Figure 6

LMF-HSFx inhibits hepatic lipotoxicity in liver tissues of mice fed with high-fat diet. (A) Liver sections stained with Hematoxylin-eosin (HE) from high-fat diet (HFD) mice or normal diet (ND) mice with or without LMF-HSFx treatment. The HE staining of liver sections was performed at 16th week from ND mice or HFD mice with or without orally gavaged LMF-HSFx (400 mg/kg/BW/day). Scale bar: 100 μm. (B) LMF-HSFx decreases the volume of lipid droplet in HFD mice liver. The differential distribution of lipid droplets in HE stained-liver tissues of HFD mice with or without 400 mg/kg/BW/day LMF-HSFx treatment after 16 weeks. The X-axis is the lipid droplets diameter and Y-axis is the total lipid droplet numbers in 10 HE stained-liver images from one mouse, n = 3 mice. X-axis unit: 103 pixel and Y-axis unit: the total lipid droplet numbers in 10 images of each area 2560 × 1922 pixel2. (C) The blood glucose (mg/dL, dL: 100 mL), (D) triglyceride (mg/dL), (E) AST (U/L) and (F) ALT (U/L) concertation in ND or HFD mice with or without 200 or 400 mg/kg/BW/day LMF-HSFx treatment through oral gavage after 16 weeks (# p < 0.05, compared with DN mice; * p < 0.05, compared with HFD mice).