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. 2021 Mar 12;19(3):148. doi: 10.3390/md19030148

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LMF-HSFx modulates SIRT-PGC-1 axis in palmitic acid-treated HepaRG hepatocytes. LMF-HSFx restored palmitic acid-induced SIRT2, 3, 6, PGC-1β and ATGL degradation. The HepaRG cells were cultured in PA 200 or 400 μM with or without LMF-HSFx 25 μg/mL. Representative Western blots of (A) SIRT-1, 2, 3, 4, 6, control protein GAPDH; (C) PGC-1α, PGC-1β, ATGL and GAPDH. Summarized bar graphs depicting the protein level of (B) SIRT-1, 2, 3, 4, 6; (D) PGC-1α, PGC-1β, ATGL. Each column represents mean ± SEM, taking the control group as 100% (* p < 0.05 compared with control; ^# p < 0.05, compared with PA200 group).