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Crystallographic pose of E2 (a), and docking poses of NRG (b) and RESV (c) in ERα (PDB ID 3uud [72]). The protein is shown in transparent green cartoon, the residues lining the binding site and the ligands are shown in capped sticks and colored green and yellow, respectively. Helices and residues lining the pocket are labelled, hydrogen bonds are displayed as black dashed lines.
