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. 2021 Mar 15;8(3):29. doi: 10.3390/jcdd8030029

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Congenital heart defects in Rac1^Nkx2.5. (A) Bifid cardiac apex in an E16.5 Rac1^Nkx2.5 heart. Arrow indicates bifurcation between the RV and LV. (B,C) Ventricular septal defect (arrowhead) was found in E15.5 Rac1^Nkx2.5 hearts with an arrow indicating the bifid cardiac apex. (D–G) Double outlet right ventricle (DORV) was found in E15.5 Rac1^Nkx2.5 hearts. The pulmonary artery and aorta were connected to the RV and LV, respectively in Rac1^f/f control hearts (D,F). However, both pulmonary artery and aorta were connected to the RV in Rac1^Nkx2.5 hearts (E,G). RA, right atrium; LA, left atrium. Scale bars: 500 µm.