Figure 4.

Ventricular myocardium abnormalities in Rac1^Nkx2.5 hearts at E15.5. In comparison to Rac1^f/f controls (A,C), the Rac1^Nkx2.5 mice (B,D) show thin compact myocardium and hypertrabeculation in the RV and LV wall. The thickness of the compact myocardium in Rac1^Nkx2.5 hearts (n = 5) was decreased while trabecular to compact myocardium ratio was increased as compared to littermate controls (n = 6) (E,F). Double-headed arrows in (A–D) indicate measurements of compact myocardium thickness. * p < 0.05, ** p < 0.01, *** p< 0.001 vs. Rac1^f/f by Student’s t-test. Scale bars: 100 µm.