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. 2021 Mar 15;8(3):29. doi: 10.3390/jcdd8030029

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Disruption of F-actin organization and cardiomyocyte polarity in Rac1^Nkx2.5 hearts. E18.5 cryosections of the heart were double stained for phalloidin and wheat germ agglutinin (WGA) to assess F-actin organization and cardiomyocyte cell polarity, respectively. The images were taken from the corresponding areas of LV myocardium free wall in Rac1^f/f and Rac1^Nkx2.5 mice. F-actin filament organization was disrupted in Rac1^Nkx2.5 myocardium (B) compared to littermate controls (A). WGA staining shows rounded cardiomyocytes in Rac1^Nkx2.5 ventricular myocardium (D) compared to the elongated cardiomyocytes in littermate controls (C). The cell borders of a cardiomyocyte in (C,D) are outlined. The short axis of cardiomyocyte diameter was significantly larger in Rac1^Nkx2.5 compared to littermates (E). ** p < 0.01 by unpaired Student’s t-test. Scale bars: 10 µm.