Table 3.

The Pharmacokinetic Parameters of DAS (A) and ROZ (B) in SD Rats Plasma After Intraperitoneal Injection of THDR-NPs and DAS + ROZ in SD Rats

A
PK Parameters	Groups
	Free DAS	THDR-NPs
AUC0–24[μg/(mL∙h)]	2.26 ± 0.93	9.44 ± 2.32*
AUC0-∞[μg/(mL∙h)]	2.38 ± 1.12	9.44 ± 4.00**
MRT0–24(h)	5.06 ± 0.94	9.39 ± 1.00**
MRT0-∞(h)	6.08 ± 2.03	30.47 ± 17.04**
Tmax(h)	0.62 ± 0.41	0.73 ± 0.15
Cmax(μg/mL)	0.44 ± 0.17	0.76 ± 0.22*
t1/2(h)	4.38 ± 1.22	29.19 ± 8.68**
B
PK Parameters	Groups
	Free ROZ	THDR-NPs
AUC0–24[μg/(mL∙h)]	41.06 ± 10.85	47.56 ± 17.21
AUC0–∞[μg/(mL∙h)]	41.34 ± 10.68	48.69 ± 17.86
MRT0–24(h)	3.04 ± 0.79	4.23 ± 0.73ˆ
MRT0–∞(h)	3.14 ± 0.77	4.57 ± 0.70ˆ
Tmax(h)	0.80 ± 0.69	2.00 ± 1.22ˆ
Cmax(μg/mL)	11.43 ± 3.79	8.67 ± 3.05
t1/2(h)	1.60 ± 0.38	2.87 ± 0.96ˆ

Notes: The results are expressed as the mean ± SD, n = 5. *p < 0.05, **p < 0.01 (DAS in THDR-NPs vs free DAS), ^{^} p < 0.05 (ROZ in THDR-NPs vs free ROZ).

Abbreviations: AUC_0–24, area under the plasma concentration-time curve from time 0 h to 24 h of quantifiable concentration; AUC_0-∞, area under the plasma concentration-time curve from time 0 extrapolated to infinite time; MRT_0–24, mean residence time of a drug molecule 0 h to 24 h; MRT_0-∞, mean residence time of a drug molecule from time 0 extrapolated to infinite time; T_max, time to reach maximum concentration; C_max, the maximum peak time; t_1/2, elimination half-life; DAS, dasatinib; ROZ, rosiglitazone; THDR-NPs, HA-DAS and TPGS mixed micelle system loaded with ROZ.