Table 3.
The Pharmacokinetic Parameters of DAS (A) and ROZ (B) in SD Rats Plasma After Intraperitoneal Injection of THDR-NPs and DAS + ROZ in SD Rats
| A | ||
| PK Parameters | Groups | |
| Free DAS | THDR-NPs | |
| AUC0–24[μg/(mL∙h)] | 2.26 ± 0.93 | 9.44 ± 2.32* |
| AUC0-∞[μg/(mL∙h)] | 2.38 ± 1.12 | 9.44 ± 4.00** |
| MRT0–24(h) | 5.06 ± 0.94 | 9.39 ± 1.00** |
| MRT0-∞(h) | 6.08 ± 2.03 | 30.47 ± 17.04** |
| Tmax(h) | 0.62 ± 0.41 | 0.73 ± 0.15 |
| Cmax(μg/mL) | 0.44 ± 0.17 | 0.76 ± 0.22* |
| t1/2(h) | 4.38 ± 1.22 | 29.19 ± 8.68** |
| B | ||
| PK Parameters | Groups | |
| Free ROZ | THDR-NPs | |
| AUC0–24[μg/(mL∙h)] | 41.06 ± 10.85 | 47.56 ± 17.21 |
| AUC0–∞[μg/(mL∙h)] | 41.34 ± 10.68 | 48.69 ± 17.86 |
| MRT0–24(h) | 3.04 ± 0.79 | 4.23 ± 0.73ˆ |
| MRT0–∞(h) | 3.14 ± 0.77 | 4.57 ± 0.70ˆ |
| Tmax(h) | 0.80 ± 0.69 | 2.00 ± 1.22ˆ |
| Cmax(μg/mL) | 11.43 ± 3.79 | 8.67 ± 3.05 |
| t1/2(h) | 1.60 ± 0.38 | 2.87 ± 0.96ˆ |
Notes: The results are expressed as the mean ± SD, n = 5. *p < 0.05, **p < 0.01 (DAS in THDR-NPs vs free DAS), ^ p < 0.05 (ROZ in THDR-NPs vs free ROZ).
Abbreviations: AUC0–24, area under the plasma concentration-time curve from time 0 h to 24 h of quantifiable concentration; AUC0-∞, area under the plasma concentration-time curve from time 0 extrapolated to infinite time; MRT0–24, mean residence time of a drug molecule 0 h to 24 h; MRT0-∞, mean residence time of a drug molecule from time 0 extrapolated to infinite time; Tmax, time to reach maximum concentration; Cmax, the maximum peak time; t1/2, elimination half-life; DAS, dasatinib; ROZ, rosiglitazone; THDR-NPs, HA-DAS and TPGS mixed micelle system loaded with ROZ.