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. 2021 Mar 7;10(3):586. doi: 10.3390/cells10030586

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Synthesis, inactivation, receptors and main metabolic functions of endocannabinoidome mediators. Thick arrows denote the biochemical reactions and functional connections underlying endocannabinoidome mediator action. Not shown, for the sake of clarity, are the negative effects exerted by almost all unsaturated N-acyl-amides tested so far on T-type (Ca_v3) Ca²⁺ channels. Blunted arrows denote inhibition. Abbreviations: 2-AG, 2-arachidonoylglycerol; 2-LG, 2-linoleoyl glycerol; 2-OG, 2-oleoyl glycerol; 5/12/15-LOX, 5/12/15-lipoxygenase; 15 HAEA, 15(S)-HETE Ethanolamide; AA, arachidonic acid; ABH4/6/12, αβ-hydrolase 4/6/12; AEA, Anandamide; CB1/2, cannabinoid receptor 1/2; COX2, cyclooxygenase 2; DAG, diacylglycerols; DHEA, N-docosahexaenoyl-ethanolamine; EET-EA, epoxyeicosatrienoic acid ethanolamide; FA, fatty acid; FAAH, fatty acid amide hydrolase; FA, free fatty acids; GDE1, glycerophosphodiester phosphodiesterase 1; GPR, G-protein-coupled receptor; LEA, N-linoleoyl-ethanolamine; MAGL, monoacylglycerol lipase; MAG, monoacylglycerols NAAA, N-acylethanolamine-hydrolysing acid amidase, NAPE, N-acyl-phosphatidylethanolamine; NAPEPLD, N-acyl-phosphatidylethanolamine-specific phospholipase D; NAT, N-acyltransferase; OEA, N-oleoyl-ethanolamine; P450, cytochrome p450 oxygenases; PEA, N-palmitoylethanolamine; PGE2, Prostaglandin E2; PLCβ, phospholipase Cβ; PPARγ, peroxisome proliferator-activated receptor γ; PPARα, peroxisome proliferator-activated receptor α; SEA, N-stearoyl-ethanolamine; TRPV1, transient receptor potential vanilloid type-1 channel; TRPV2, transient receptor potential vanilloid type-2 channel.