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Representative mechanism of PPARα gene regulation by CB1 receptors. (A) In absence of CB1 ligands, p53 and miRNA22 suppress the activity of SIRT1 which positively regulates PPARα. (B) In presence of CB1 agonists, p53 and miRNA22 are inhibited and SIRT1 activates PPARα which forms a heterodimer with RXR, to bind PPRE elements of target genes.
