Figure 3.

ThT analysis of the relative islet amyloid polypeptide (IAPP)-amyloid inhibiting propensity exerted by TTR-wt, L12P, V30M, V30G, L55P, F64S, Y69H, T119M, and the monomeric variant TTR-M. The lag-phase of the TTR-wt versus control was set to 1.0, and the effect from all other TTR-variants were normalized accordingly (A). The relative inhibitory effects of the specific TTR-variants are plotted as a function of kinetic stability represented by the dissociation-rate of the tetramer (B) and thermodynamic stability (C). An inverse correlation between the inhibitory effect and thermodynamic stability is shown (r² = 0.53 and p-value < 0.0001).