Figure 2.

Bliss independence surface analysis for interaction of LMM6 with antifungal conventional drugs (AMB: amphotericin B; CAS: caspofungin; FLC: fluconazole; ITC: itraconazole). Evaluated effect against reference strain (A–D) and one clinical isolate from hospitalized patient blood (SangHUMCa7; (E–H)). The x axes represent the antifungal conventional drugs and y axes the LMM6. The magnitude of interactions is directly related to percent ΔE (%ΔE; z axes). Interactions with positive %ΔE represent synergistic effect statistically significant whereas that combinations with negative %ΔE indicate antagonism or no effect. The experimental data were analyzed independently using the Combenefit software.