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. 2021 Mar 1;10(3):272. doi: 10.3390/pathogens10030272

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of diluted antiseptics on infection by replication-competent severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) virus when antiseptics were present in the culture. (A) Replication competent virus SARS-CoV-2 expressing mNeonGreen (multiplicity of infection (MOI) of 5) were mixed or not with Listerine (3%), CHG (1.5%), povidone-iodine (0.1%), or Colgate Peroxyl (0.05%), and immediately added (in 50 μL) to Vero cells and incubated 1 h for viral attachment. Antiseptics were diluted by the addition of 100 μL of the medium to reduce potential toxic effects. Fluorescence intensity derived from productive viral infection was determined at 24 h after infection. (B) Cell images were acquired on a Bioteck Cystatin 5 plate reader. Differences between mouth rinse-treated viruses and the medium control (0%) were compared; * p < 0.05. Data are means ±SD and are representative of three independent experiments.