Figure 6.
The effect of mouth rinses on replication-competent SARS-CoV-2 viruses. (A) Mouth rinses and povidone-iodine at the indicated dilutions were added to replication-competent SARS-CoV-2 expressing mNeonGreen (1 × 106 plaque-forming units). Treated and untreated viruses were immediately pelleted by centrifugation, and the supernatant was aspirated. Virus pellets were resuspended in Fluorobrite medium with 2% FBS and added to Vero cells. Viral infection was determined by measuring fluorescence intensity at 24 h after infection. (B) Images of infected cells with or without mouth rinse treatment were acquired when the plate was read. Differences between mouth rinse- and medium control (0%)-treated viruses were compared; * p < 0.05. Data are means ±SD and are representative of two independent experiments.