Table 3.

In vivo regulatory effects of phytochemicals on lncRNAs in various mouse xenograft tumor models.

Phytochemical	Cancer Type	Dose	Target lncRNAs	Biological Functions	Reference
Baicalein	Cervical cancer	10 mg/kg/day	lncRNA- BDLNR↓	Inhibits tumor growth	[23]
	Hepatocellular carcinoma	10 mg/kg/day	NKILA↑	Inhibits tumor growth	[118]
	Breast cancer	10 mg/kg/day	PAX8-AS1-N↑	Inhibits tumor growth	[119]
Berberis	Non-small cell lung carcinoma	25 mg/kg/day	HOTAIR↓	Inhibits tumor growth	[27]
Calycosin	Breast cancer	55 mg/kg/day	WDR7-7↑	Inhibits tumor growth	[122]
	Nasopharyngeal carcinoma	60 mg/kg/day	EWSAT1↓	Inhibits tumor growth	[124]
Curcumin	Pancreatic ductal adenocarcinoma	100 mg/kg/day	lncRNA-PVT1↓	Inhibits tumor growth	[125]
DIM	Prostate cancer	20 mg/kg/day	PCGEM1↓	Inhibits tumor growth	[135]
EGCG	Non-small cell lung carcinoma	20 mg/kg/day	lncRNA-NEAT1↑	Inhibits tumor growth	[137]
	Osteosarcoma	30 mg/kg/day	SOX2OT V7↓	Inhibits tumor growth	[138]
Genistein	Colorectal cancer	30 mg/kg/day	lncRNA-TTTY18↓	Inhibits tumor growth	[144]
Ginsenosides	Pancreatic cancer	40 mg/kg/day	CASC2↑	Inhibits tumor growth	[147]
Hyperoside	Non-small-cell lung carcinoma	25 mg/kg/day	CCAT1↓	Inhibits tumor growth	[150]
Luteolin	Thyroid carcinoma	50 mg/kg/day	BANCR↓	Inhibits tumor growth	[151]
Polydatin	Osteosarcoma	150 mg/kg/day	TUG1↓	Inhibits tumor growth	[152]
Quercetin	Prostate cancer	75 mg/kg/day	MALAT1↓	Inhibits tumor growth	[153]

↓, downregulation; ↑, upregulation; DIM, 3,3′-diindolylmethane; EGCG, epigallocatechin-3-gallate.