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. 2021 Mar 10;22(6):2819. doi: 10.3390/ijms22062819

Figure 1.

Figure 1

Dimethyl sulfoxide (DMSO) time- and dose-dependent changes of overall phosphorylation levels in eight lung cancer in vitro models. Broad change in protein phosphorylation levels was measured as aggregate changes of the Reverse Phase Protein Array (RPPA) intensity values across 125 post-translationally modified kinases and downstream substrates within each cell line. Tallied values for each cell line were normalized to the baseline (T0) of the corresponding DMSO concentration and expressed as fold change of the untreated values (C1 Panel A, C2 Panel B, and C3 Panel C, respectively). For each timepoint and DMSO concentration, technical replicates were collected (n = 3) and mean and standard error of the mean are shown. Adjusted pair-wise comparisons that retained statistical significance (* p < 0.05; ** p < 0.01, respectively) are shown for each cell line.