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. 2021 Mar 13;22(6):2939. doi: 10.3390/ijms22062939

Figure 2.

Figure 2

Integrity of DA and NE systems of middle-aged (5 months) A30P*A53T*α-Syn transgenic mice. (a) TH-immunostained brain sections containing SNc/VTA, LC and CPu. Scale bar: 200 µm. (b) No differences in the number of TH+ neurons were found in the SNc, VTA or LC of A30P*A53T*α-Syn vs. non-Tg mice. Likewise, the density of striatal TH+ terminals was comparable between both phenotypes. (c) DAT-immunostained brain sections containing SNc/VTA and CPu. Scale bar: 200 µm. (d) No differences in DAT protein density were found in the SNc, VTA or CPu of A30P*A53T*α-Syn vs. non-Tg mice. (e) Confocal images showing the NET protein density in LC and mPFC of A30P*A53T*α-Syn and non-Tg mice. Scale bar: 200 µm. (f) No differences in NET protein density were found in LC and mPFC of both phenotypes. Data are represented as mean ± SEM, n = 4–5 mice/group. Abbreviations: mPFC, medial prefrontal cortex; CPu, caudate putamen; HPC, hippocampus; SNc, substantia nigra compacta; VTA, ventral tegmental area; DR, dorsal raphe nucleus; LC, locus coeruleus.