Table A1.
Clinicopathological features of PTC and miR-146b, -21, -221, -222, and -181b expression in papillary thyroid carcinoma tissue samples.
| Relative Expression 2-∆Ct: MEAN ± SD | |||||
|---|---|---|---|---|---|
| PTC Clinicopathological Feature | miR-146b | miR-21 | miR-221 | miR-222 | miR-181b |
| Age | |||||
| <55 years (n= 174; 55.77%) | 3.414 ± 0.229 | 1.486 ± 0.096 | 0.749 ± 0.061 | 2.496 ± 0.155 | 0.0006 ± 0.00004 |
| ≥55 years (n = 138; 44.23%) | 3.701 ± 0.291 | 1.630 ± 1.132 | 0.838 ± 0.078 | 2.423 ± 0.153 | 0.0006 ± 0.00004 |
| p | 0.576 | 0.439 | 0.343 | 0.764 | 0.300 |
| Sex | |||||
| Male (n = 33; 10.58%) | 3.544 ± 0.588 | 1.465 ± 0.174 | 0.646 ± 0.104 | 2.478 ± 0.336 | 0.0006 ± 0.00006 |
| Female (n = 279; 89.42%) | 3.541 ± 0.191 | 1.560 ± 0.086 | 0.806 ± 0.053 | 2.462 ± 0.116 | 0.0006 ± 0.00003 |
| p | 0.910 | 0.794 | 0.433 | 0.992 | 0.518 |
| Multifocality | |||||
| Single (n = 244; 79.20%) | 3.673 ± 0.211 | 1.658 ± 0.096 | 0.843 ± 0.595 | 2.548 ± 0.130 | 0.0006 ± 0.00003 |
| Multiple (≥2) (n = 68; 21.80%) | 3.123 ± 0.343 | 1.177 ± 0109 | 0.605 ± 0.0629 | 2.196 ± 0.188 | 0.0006 ± 0.00004 |
| p | 0.327 | 0.011 | 0.054 | 0.416 | 0.850 |
| Extrathyroidal extension | |||||
| Yes (n = 131; 41.99%) | 3.289 ± 0.280 | 1.644 ± 0.113 | 0.905 ± 0.087 | 2.606 ± 0.156 | 0.0005 ± 0.00004 |
| No (n = 181; 58.01%) | 3.383 ± 0.237 | 1.487 ± 0.109 | 0.709 ± 0.055 | 2.374 ± 0.152 | 0.0006 ± 0.00004 |
| p | 0.086 | 0.082 | 0.049 | 0.030 | 0.108 |
| Lymphovascular invasion | |||||
| Yes (n = 139; 44.55%) | 3.647 ± 0.245 | 1.583 ± 0.091 | 0.826 ± 0.067 | 2.528 ± 1.328 | 0.0006 ± 0.00004 |
| No (n = 173; 55.45%) | 3.434 ± 0.271 | 1.515 ± 1.283 | 0.746 ± 0.071 | 2.399 ± 0.181 | 0.0006 ± 0.00004 |
| p | 0.420 | 0.204 | 0.300 | 0.103 | 0.462 |
| T (TNM) | |||||
| pT1a, pT1b (n = 166; 53.2%) | 3.220 ± 0.241 | 1.386 ± 0.933 | 0.642 ± 0.477 | 2.158 ± 0.136 | 0.0007 ± 0.00004 |
| pT2, pT3, pT4 (n = 146; 46.8%) | 3.880 ± 0.269 | 1.721 ± 0.128 | 0.943 ± 0.842 | 2.786 ± 0.171 | 0.0006 ± 0.00004 |
| p | 0.032 | 0.044 | 0.003 | 0.001 | 0.317 |
| Lymph node metastases | |||||
| Yes (n = 48; 15.38%) | 4.488 ± 0.539 | 2.054 ± 0.0288 | 1.108 ± 0.188 | 3.496 ± 0.355 | 0.0008 ± 0.00009 |
| No (n=264; 84.62%) | 3.370 ± 1.889 | 1.458 ± 0.077 | 0.731 ± 0.046 | 2.276 ± 0.109 | 0.0006 ± 0.00003 |
| p | 0.057 | 0.014 | 0.037 | <0.0001 | 0.01 |
| Autoimmune thyroiditis | |||||
| Yes (n = 78; 25%) | 4.155 ± 0.416 | 1.889 ± 0.198 | 0.794 ± 0.091 | 2.720 ± 0.266 | 0.0006 ± 0.00006 |
| No (n = 234; 75%) | 3.350 ± 0.197 | 1.440 ± 0.082 | 0.790 ± 0.676 | 2.388 ± 0.116 | 0.0006 ± 0.00003 |
| p | 0.102 | 0.007 | 0.675 | 0.546 | 0.818 |