Table 1.

Pros and cons of using saRNAs as therapeutics.

Advantages	Disadvantages
Effective gene activation	Poor cellular uptake
Locus-specific activation of gene transcription, including undruggable targets	High sensitivity to RNase degradation
Easy to manufacture	Renal clearance
Cost-effectiveness	Repeated administration
Low toxicity	Off-target effects
Easy large-scale production	Activation of Toll-like receptors
Poor immunogenicity