H3K4me3 associated with favorable outcome in higher GPER-expressing (IRS = 6–12) EOC patients. The prognostic significance of H3K4me3 was evaluated in subgroups of patients with high- (IRS = 6–12, (A)) compared to low-level (IRS = 0–4, (B)) GPER expression. Survival of patients with high levels of H3K4me3 expression (IRS = 9–12) (green lines) was compared to those with lower H3K4me3 expression (IRS = 0–8) (blue lines) by the log-rank text and Kaplan–Meier survival analysis. Notably, H3K4me3 predicts significantly better outcome in the subgroup classified as high-level GPER expression (left, (A)) compared to low-level GPER expression (right, (B)).